Luciferas 4T1 Breast Cancer Cells (4T1-Luc)

The 4T1-LUC cell line is a widely used murine breast cancer cell line that has been engineered to express the luciferase gene, allowing for non-invasive monitoring of tumor growth and metastasis in live animals using bioluminescence imaging. The 4T1 cell line was originally derived from a spontaneously arising mammary tumor in a BALB/cfC3H mouse and has since become a valuable model for studying breast cancer progression and metastasis.

By introducing the luciferase reporter gene into the 4T1 cell line, researchers can easily track the growth of primary tumors and the spread of metastatic lesions in preclinical studies. Luciferase-expressing cells emit light when they come into contact with a specific substrate, such as luciferin, allowing for real-time visualization and quantification of tumor growth and dissemination in vivo.

The 4T1-LUC cell line is known for its high metastatic potential, resembling aggressive forms of breast cancer in patients. This cell line is commonly used to investigate key aspects of breast cancer biology, including tumor invasion, metastasis to distant organs, immune interactions, and responses to various therapeutic interventions.