MV4-11 Myeloid Monocytic Leukemia Cells (MV4-11)

MV-4-11 cells are macrophages that were isolated from the blast cells of a 10-year-old male with biphenotypic B-myelomonocytic leukemia and deposited by the Wistar Institute.  The MV4-11 cell line is commonly used in cancer research. It was derived from the bone marrow of a patient with acute myeloid leukemia and is used for studying the biology of leukemia, testing chemotherapeutic agents, and exploring the underlying mechanisms of drug resistance.

MV4-11 cells are particularly noted for expressing the FLT3 receptor, which is often mutated in AML cases, and these mutations can significantly affect the behavior of the cancer and its response to treatment. Due to this characteristic, MV4-11 cells are frequently employed in studies looking to develop targeted therapies for FLT3-mutated AML.