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Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2)

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NFAT1; NFATP; NF-ATP; NFAT pre-existing subunit; T-cell transcription factor NFAT1

Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2)
CCC L942
HGNC 7776
MGI 102463
PubMed 19318479
RGD 1307690
UniProt Q13469
Wiki NFATC2
NFATC2 is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.A truncated form of NFATP, expressed as a recombinant protein in bacteria, bound specifically to the NFAT site of the murine IL2 promoter and formed a transcriptionally active complex with recombinant FOS and JUN.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPL942Hu01 Recombinant Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies MAL942Hu21 Monoclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) WB; IHC; ICC; IP.
PAL942Hu01 Polyclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) WB; IHC; ICC; IP.
Assay Kits SEL942Hu ELISA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nuclear Factor Of Activated T-Cells, Cytoplasmic 2 (NFATC2) ELISA Kit Customized Service Offer
  1. "Recombinant NFAT1 (NFATp) is regulated by calcineurin in T cells and mediates transcription of several cytokine genes."Mol. Cell. Biol. 16:3955-3966(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing and expression of human and mouse NFAT genes."Genomics 92:279-291(2008) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT."Cell 96:611-614(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells."Proc. Natl. Acad. Sci. U.S.A. 102:5138-5143(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Nine-amino-acid transactivation domain: establishment and prediction utilities."Genomics 89:756-768(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  11. "NFAT promotes carcinoma invasive migration through glypican-6."Biochem. J. 440:157-166(2011) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]