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Fat Mass And Obesity Associated Protein (FTO)

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Alpha-ketoglutarate-dependent dioxygenase FTO

Fat Mass And Obesity Associated Protein (FTO)
CCC N274
HGNC 24678
MGI 1347093
PubMed 21103374
RGD 1305121
UniProt Q9C0B1
Wiki FTO
The predicted 502-amino acid Fto protein has a calculated molecular mass of 58 kD and contains an N-terminal bipartite nuclear localization signal. RT-PCR detected Fto expression throughout mouse embryonic development and in all adult mouse tissues examined except heart and skin.
FTO shares sequence motifs with iron- and 2-oxoglutarate (2OG)-dependent oxygenases.Consistent with a potential role in nucleic acid demethylation, Fto localized to the nucleus in transfected cells. Studies of wildtype mice indicated that Fto mRNA is most abundant in the brain, particularly in hypothalamic nuclei governing energy balance, and that Fto mRNA levels in the arcuate nucleus are regulated by feeding and fasting.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
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Antibodies n/a Monoclonal Antibody to Fat Mass And Obesity Associated Protein (FTO) Monoclonal Antibody Customized Service Offer
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Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fat Mass And Obesity Associated Protein (FTO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fat Mass And Obesity Associated Protein (FTO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fat Mass And Obesity Associated Protein (FTO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fat Mass And Obesity Associated Protein (FTO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fat Mass And Obesity Associated Protein (FTO) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Fat Mass And Obesity Associated Protein (FTO) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Fat Mass And Obesity Associated Protein (FTO) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Fat Mass And Obesity Associated Protein (FTO) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Fat Mass And Obesity Associated Protein (FTO) CLIA Kit Customized Service Offer
n/a ELISA Kit for Fat Mass And Obesity Associated Protein (FTO) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  2. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Variation in FTO contributes to childhood obesity and severe adult obesity." Nat. Genet. 39:724-726(2007) [PubMed] [Europe PMC] [Abstract]
  5. "A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity." Science 316:889-894(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTO."FEBS Lett. 582:3313-3319(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "N6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO."Nat. Chem. Biol. 7:885-887(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structure of the FTO protein reveals basis for its substrate specificity."Nature 464:1205-1209(2010) [PubMed] [Europe PMC] [Abstract]
  11. "Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations."Am. J. Hum. Genet. 85:106-111(2009) [PubMed] [Europe PMC] [Abstract]