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Recombinant Deoxyribonuclease I (DNASE1)

DNaseI; DNL1; DRNI; DNase-I; Dornase alfa

  • Product No.RPB127Hu01
  • Organism SpeciesHomo sapiens (Human) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationNucleus, Secreted
  • Predicted Molecular Mass28.3kDa
  • Accurate Molecular Mass28kDa(Analysis of differences refer to the manual)
  • Residues & TagsGly19~Ala259 with N-terminal His Tag
  • Buffer Formulation20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder
  • Purity> 90%
  • Isoelectric Point4.6
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 112  US$ 280  US$ 560  US$ 1680  US$ 4200 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
J Card Fail Low Circulating Levels of Mitochondrial and High Levels of Nuclear DNA Predict Mortality in Chronic Heart Failure Pubmed:27349571
Biochimie Inhibition of nuclease activity by a splice-switching oligonucleotide targeting deoxyribonuclease 1 mRNA prevents apoptosis progression and prolong viability of … Pubmed: 32315661
Scientific Reports Biomarkers of neutrophil extracellular traps (NETs) and nitric oxide-(NO)-dependent oxidative stress in women who miscarried Pubmed: 32753622
J Am Heart Assoc DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross‐Sectional Study in Mice and Humans Pubmed:35023342
Catalog No. Related products for research use of Homo sapiens (Human) Organism species Applications (RESEARCH USE ONLY!)
APB127Hu01 Active Deoxyribonuclease I (DNASE1) Cell culture; Activity Assays.
RPB127Hu01 Recombinant Deoxyribonuclease I (DNASE1) Positive Control; Immunogen; SDS-PAGE; WB.
PAB127Hu01 Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC
LAB127Hu81 FITC-Linked Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
LAB127Hu71 Biotin-Linked Polyclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC.
MAB127Hu22 Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB,IHC
MAB127Hu21 Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IP.
LAB127Hu82 FITC-Linked Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC; IF.
LAB127Hu72 Biotin-Linked Monoclonal Antibody to Deoxyribonuclease I (DNASE1) WB; IHC; ICC.
SEB127Hu ELISA Kit for Deoxyribonuclease I (DNASE1) Enzyme-linked immunosorbent assay for Antigen Detection.
LMB127Hu Multiplex Assay Kit for Deoxyribonuclease I (DNASE1) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.