The cardiovascular system is composed of the heart and blood vessels. The heart sends blood to the arteries of the whole body, and exchanges nutrients, oxygen and metabolic waste through capillaries. After that, the blood enters the veins and is transported back to the heart by the veins of the whole body to complete the circulation. When the heart and its connected blood vessels appear pathological changes, it is called cardiovascular disease, including insufficient blood supply to the heart, arrhythmia, cardiac hypertrophy, cardiovascular disease, etc.,which can affect the function of the cardiovascular system.MacrophagesAs an important component of innate immunity, macrophages are w......2021-11-01

CD45 is expressed on all white blood cells and is called theleukocyte common antigen. CD45 is composed of a class of transmembrane proteins with similar structure and large molecular weight. Its cytoplasmic region acts as a protein tyrosine phosphatase, which can dephosphorylate and activate tyrosine on the substrate and play an important role in cell information transmission. As a key molecule of signal transduction on the cell membrane, CD45 plays an important role in development, maturation, function regulation and signal transmission of lymphocytes. In addition, according to the different types of CD45 molecule expressed by T cells, human T cells can be divided into CD45RA+ naive T......2021-10-27

CD25 is the α chain of IL-2R and a characteristic marker molecule on the surface of regulatory T (Treg) cells. Treg cells have immunosuppressive effects by inhibiting Th cells, CD8+T cell proliferation and activation, as well as NK cell-mediated killing activity. On the one hand, it can induce autoimmune tolerance, so as to maintain the stable state of the body and avoid the occurrence of autoimmune diseases; On the other hand, it can inhibit the formation and maintenance of tumor immune mechanism. Therefore, CD25 detection is of great significance in the prevention and treatment of autoimmune diseases and clinical tumors.2021-10-21

Pulmonary fibrosis (PF) is a major category of terminal changes of lung diseases characterized by proliferation of fibroblasts, accumulation of a large amount of extracellular matrix, accompanied by inflammatory damage and destruction of tissue structure, namely, structural abnormalities caused by abnormal repair of normal alveolar tissue after damage. The cause of most PF is unknown and is called idiopathic interstitial pneumonia. In idiopathic interstitial pneumonia, the most common disease type with PF lesions as the main manifestation is idiopathic PF, which is an interstitial lung disease that can lead to progressive loss of lung function.New progress in the research on the pathog......2021-10-19

CD8 refers to a molecule expressed on the surface of T lymphocytes. T lymphocytes expressing this molecule are called CD8+ T lymphocytes, which are cytotoxic T lymphocytes that can kill kill the human cells infected by the virus and tumor cells,block the replication and spread of viruses and the spread of tumors. Under normal circumstances, CD8 lymphocytes account for about 35% of all T lymphocytes. The increase of CD8+ T lymphocytes should consider that the human body is suffering from viral infection or the appearance of tumors, so CD8 detection is helpful for the diagnosis of certain infectious diseases and immune diseases.2021-10-13

The dangers of obesityThe persistent imbalance between energyintake and energy consumption results inobesity, which causes acommon disorder called metabolic syndrome, with various comorbidities. These include type 2 diabetes, hypertension, nonalcoholic steatohepatitis(NASH), cardiovascular diseases and cancer, which may lead to death. Worldwide, 1.9 billion adults are overweight and 600 million are obese, and 51% of the global population is predicted to be obese by 2030. Thus, obesity is a major global health problem with increasingly alarming incidence.New targets for obesity treatmentDespite efforts to find safe, effective obesity treatments, current options are limited, mainly due t......2021-09-29