Breast cancer (BC) is the most common malignancy in women. Due to advances in early diagnosis and comprehensive treatment strategies, the prognosis of breast cancer patients has improved. The disease has been divided into different subtypes, largely on the basis of the presence or absence of three key proteins: estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2/ERBB2). Among them, triple negative breast cancer (TNBC) with negative expression of ER, PR and HER2/ERBB2 is the most difficult type of breast cancer treatment at present.New treatment strategies for TNBCTNBC has been characterized by several aggressive clinical features inclu......2021-11-18

Due to the small molecular weight, poor immunogenicity, and many homologs of chemical small molecules, the development of immunoassay kits is often difficult, and high-quality small molecule immunoassay kits are even more difficult to obtain.Cloud-Clone CORP. WUHAN, has developed small molecule detection kits as its own characteristic project from the beginning of its establishment, and has developed and accumulated small molecule modification and coupling technology, small molecule immunity technology and homolog screening technology for nearly 10 years. It has formed its own technical system in small molecule modification, immunity and antibody preparation. Up to now, the small molec......2021-11-17

Cytokines are a class of low molecular weight soluble proteins gradually formed in the evolution of higher animals in response to the changes in the internal and external environment of organisms. They have many functions such as regulating innate immunity, adaptive immunity, hematopoiesis, cell growth and repair of damaged tissues. At present, more than 100 types of cytokines have been discovered, which can be divided into interleukin (IL), interferon (IFN), colony stimulating factor (CSF), tumor necrosis factor (TNF), erythropoietin (EPO) and other types according to their functions. With the further research, the total number of cytokines has changed year by year. After more than 10......2021-11-17

Journal: Molecular PsychiatryIF: 15.992On September 1, 2021, Edward J. Goetzl from University of California, San Francisco School of Medicine, and his team , published a paper titled "Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder" on Molecular Psychiatry, to evaluate whether plasma neuronal extracellular vesicles mitochondrial proteins can be used as biomarkers and drug targets for major depressive disorder.The ELISA Kits (ELISA Kit for Mitochondrial Open Reading Frame Of The 12S rRNA-c (MOTS-c), CEX132Hu) of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.To charac......2021-11-16

BRD4 is a transcriptional and epigenetic regulator that plays a pivotal role during embryogenesis and cancer development.As amember of the Bromodomains and Extraterminal (BET) family, BRD4 is characterized by two tandem bromodomains (BD1, BD2).BDs bind acetylated lysine residues on target proteins, including histones. Being itsaffinity higher for proteins with multiple acetylated residues, BRD4 interactswith hyper-acetylated histone regions along the chromatin, accumulating on transcriptionally active regulatory elements and promoting gene transcription both at initiation and elongation step.BRD4 and cancerNeuroblastoma (NB), a solid malignancy featured by rapid progression and high mo......2021-11-16

Journal：Journal of Cachexia, Sarcopenia and MuscleIF：12.910On September 18, 2021, Laurence Genton and his team from the Department of Nutrition at the University Hospital of Geneva, Switzerland, published a paper titled "Gut barrier and Microbiota Changes with Glycine and colon-chain amino acid Early Supplementation in Chronic Haemodialysis patients" on Journal of Cachexia,Sarcopenia and Muscle. To assess whether glycine or branched chain amino acid (BCAA) supplementation is associated with changes in intestinal barrier and microbiota in patients with chronic hemodialysis (HD).The ELISA Kits (ELISA Kit for Lipopolysaccharide (LPS), SEB526Hu) of Cloud-Clone brand was chose......2021-11-08