Metabolic diseases, including diabetes, obesity, non-alcoholic fatty liver disease (NAFLD), hyperlipidemia, and gout, have become major public health issues worldwide.Current therapy for metabolic diseases includes lifestyle interventions, balanced diet, appropriate exercise, and the use of pharmacological drugs. However, these drugs still have some limitations because of adverse effects.Targeting insulin resistance to treat metabolic diseasesInsulin resistance(IR) is a common pathophysiological condition in which patients present with reduced insulin sensitivity and thus glucose intolerance, andunable to obtain to process the required energy from glucose to maintain cellular metabolic......2022-01-17

On December 6, 2021, Li Tang, Institute of Materials Science and Engineering, École polytechnique fédérale de Lausanne (EPFL), and his team published an article titled “Cancer-cell stiffening via cholesterol depletion enhances adoptive T-cell immunotherapy”in Nature Biomedical Engineering, which revealed a mechanical immune checkpoint that could be targeted therapeutically to improve the effectiveness of cancer immunotherapies.The protein [Active Perforin 1 (PRF1), APB317Mu01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Malignant transformation and tumour progression are associated with cancer-cell softening. Yet how the biomec......2022-01-12

Conventional chemotherapy and targeted therapy constitute an important part of first-line therapy for cancer management.Most patients with early-stage tumors achieve complete or partial response after chemotherapy and targeted therapy, while patients with advanced tumors often have poor treatment outcomes.Cancer cells evade the cytotoxicity of chemotherapy and targeted therapy through multifactorial intrinsic and acquired drug resistance mechanisms, and drug resistance is the main cause of chemotherapy failure.Study on drug resistance mechanism of tumor cellsThe development of drug resistance is a major challenge in cancer treatment. Adaptation in cancer therapy promotes drug resistanc......2022-01-10

On October 23, 2021, Weiming Tian, Laboratory for Space Environment and Physical Sciences, Harbin Institute of Technology, and his team published an article titled "A novel neuroinflammation-responsive hydrogel based on mimicking naked mole rat brain microenvironment retards neurovascular dysfunction and cognitive decline in Alzheimer’s disease" in Chemical Engineering Journal, which provided a potential early intervention strategy for retarding later AD progression.The antibody [Monoclonal Antibody to Hyaluronic Acid (HA), MAA182Ge21] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Neuroinflammation is one of the major proces......2022-01-06

Alzheimer’s disease (AD), the most common cause of agerelated dementia, represents one of the most urgent healthcare challenges facing us today with numbers affected projected to increase 50 million worldwide to 75 million by 2030 in line with an aging global population.It is pathologically characterized by abnormal accumulation of amyloid β (Aβ) as amyloid plaques, hyperphosphorylated tau in the form of neurofibrillary tangles, and neuroinflammation in the brain.Research progress in the pathogenesis and potential treatment of ADIn the past several decades, many studies have been carried out to investigate cerebrospinal fluid biomarkers (tau and Aβ), neuroimaging measurements of h......2021-12-30

Proliferating Cell Nuclear Antigen (PCNA) was first discovered and named after Miyachi et al in the serum of patients with systemic lupus erythematosus (SLE) in 1978. It is named after it only exists in normal Proliferating cells and tumor cells. Later studies found that PCNA was closely related to cell DNA synthesis and played an important role in the initiation of cell proliferation, which was a good indicator of cell proliferation status. PCNA has certain correlation with the occurrence and development, grade, stage, radiotherapy sensitivity, prognosis, recurrence and metastasis of various tumors. Therefore, PCNA plays an important role in the early diagnosis, therapeutic effect mon......2021-12-29