Interleukin 1 Alpha (IL1a)
[Edit]IL1-A; IL-1α; IL1F1; Preinterleukin 1 Alpha; Hematopoietin-1; Pro-Interleukin-1-Alpha; Interleukin-1 Family Member 1
-90071.jpg)
IL-1α is a member of interleukin 1 family. IL-1α and IL-1β recognize the same IL-1 receptor and share a number of similar biological functions. IL-1α is predominantly a cell-associated molecule whereas IL-1β is a secreted molecule.
IL-1α is synthesized primarily as a 31 kDa precursor that lacks a signal peptide. Cleavage of the precursor is via the cysteine protease calpain, resulting in a 17.5 kDa mature IL-1 molecule. Being active in the processed form, the IL-1 precursor is also biologically active via specific cell binding. A portion of the precursor is transported to the cell surface and associated with the cell membrane. Precursor IL-1α can be released and cleaved by extracellular proteases when the cells die, and can also be cleaved by activation of the calcium-dependent, membrane-associated calpains.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA071Mu01 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA071Mu02 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA071Mu01 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. |
| PAA071Mu02 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA071Mu | ELISA Kit for Interleukin 1 Alpha (IL1a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
| HEA071Mu | High Sensitive ELISA Kit for Interleukin 1 Alpha (IL1a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
Organism species: Cavia (Guinea pig )
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA071Gu01 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA071Gu01 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. |
| MAA071Gu21 | Monoclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA071Gu | ELISA Kit for Interleukin 1 Alpha (IL1a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA071Rb01 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA071Rb02 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA071Rb52 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. |
| PAA071Rb51 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| LAA071Rb71 | Biotin-Linked Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC. | |
| PAA071Rb01 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA071Rb | ELISA Kit for Interleukin 1 Alpha (IL1a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Canis familiaris; Canine (Dog)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA071Ca01 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| RPA071Ca02 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. | |
| Antibodies | PAA071Ca01 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. |
| LAA071Ca71 | Biotin-Linked Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC. | |
| MAA071Ca21 | Monoclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| PAA071Ca02 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA071Ca | ELISA Kit for Interleukin 1 Alpha (IL1a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Sus scrofa; Porcine (Pig)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA071Po01 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA071Po01 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. |
| LAA071Po71 | Biotin-Linked Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC. | |
| MAA071Po21 | Monoclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA071Po | ELISA Kit for Interleukin 1 Alpha (IL1a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Bos taurus; Bovine (Cattle)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA071Bo01 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA071Bo01 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. |
| MAA071Bo21 | Monoclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA071Bo | ELISA Kit for Interleukin 1 Alpha (IL1a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Capra hircus; Caprine (Goat)
Organism species: Ovis aries; Ovine (Sheep)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA071Ov01 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | PAA071Ov01 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. |
| MAA071Ov21 | Monoclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| Assay Kits | SEA071Ov | ELISA Kit for Interleukin 1 Alpha (IL1a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Equus caballus; Equine (Horse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPA071Eq01 | Recombinant Interleukin 1 Alpha (IL1a) | Positive Control; Immunogen; SDS-PAGE; WB. |
| APA071Eq61 | Active Interleukin 1 Alpha (IL1a) | Cell culture; Activity Assays. | |
| Antibodies | PAA071Eq01 | Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. |
| LAA071Eq71 | Biotin-Linked Polyclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC. | |
| MAA071Eq21 | Monoclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| MAA071Eq24 | Monoclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| LAA071Eq74 | Biotin-Linked Monoclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC. | |
| MAA071Eq26 | Monoclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC; IP. | |
| LAA071Eq76 | Biotin-Linked Monoclonal Antibody to Interleukin 1 Alpha (IL1a) | WB; IHC; ICC. | |
| Assay Kits | SEA071Eq | ELISA Kit for Interleukin 1 Alpha (IL1a) | Enzyme-linked immunosorbent assay for Antigen Detection. |
- "Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs."Nature 315:641-647(1985) [PubMed] [Europe PMC] [Abstract]
- "Complete nucleotide sequence of the gene for human interleukin 1 alpha."Nucleic Acids Res. 14:3167-3179(1986) [PubMed] [Europe PMC] [Abstract]
- "Cloning and characterization of the cDNAs for human and rabbit interleukin-1 precursor."Nucleic Acids Res. 13:5869-5882(1985) [PubMed] [Europe PMC] [Abstract]
- "Cloning of the cDNA coding for human prointerleukin-1 alpha and prointerleukin-1 beta."Dokl. Akad. Nauk SSSR 309:1005-1008(1989) [PubMed] [Europe PMC] [Abstract]
- "Recombinant human interleukin 1 alpha: purification and biological characterization."J. Immunol. 136:2492-2497(1986) [PubMed] [Europe PMC] [Abstract]
- "cDNA cloning of IL-1 alpha and IL-1 beta from mRNA of U937 cell line."Biochem. Biophys. Res. Commun. 143:345-352(1987) [PubMed] [Europe PMC] [Abstract]
- "A sequence-based map of the nine genes of the human interleukin-1 cluster."Genomics 79:718-725(2002) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Effects of hematopoietin-1 and interleukin 1 activities on early hematopoietic cells of the bone marrow."Blood 71:962-968(1988) [PubMed] [Europe PMC] [Abstract]
- "The 31-kDa precursor of interleukin 1 alpha is myristoylated on specific lysines within the 16-kDa N-terminal propiece."Proc. Natl. Acad. Sci. U.S.A. 90:7245-7249(1993) [PubMed] [Europe PMC] [Abstract]
- "Structure of interleukin 1 alpha at 2.7-A resolution."Biochemistry 29:2679-2684(1990) [PubMed] [Europe PMC] [Abstract]