≡

Octamer Binding Transcription Factor 4 (OCT4)

[Edit]

POU5F1; OCT3; OTF3; OTF4; Octamer-4; POU Domain Class 5 Transcription Factor 1; POU Class 5 Homoeobox 1; Octamer-binding protein 3

Octamer Binding Transcription Factor 4 (OCT4)
CCC A424
HGNC 9221
MGI 101893
PubMed 16518401
RGD 1359491
UniProt Q01860
Wiki Oct-4

Oct-4 is a homeodomain transcription factor of the POU family. This protein is critically involved in the self-renewal of undifferentiated embryonic stem cells. As such, it is frequently used as a marker for undifferentiated cells. Oct-4 expression must be closely regulated; too much or too little will actually cause differentiation of the cells.

Oct-4 transcription factor is initially active as a maternal factor in the oocyte but remains active in embryos throughout the preimplantation period. Oct-4 expression is associated with an undifferentiated phenotype and tumors. In fact gene knockdown of Oct-4 promotes differentiation, thereby demonstrating a role for these factors in human embryonic stem cell self-renewal.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA424Hu01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA424Hu01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
MAA424Hu21 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
MAA424Hu22 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
MAA424Hu23 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
MAA424Hu24 Monoclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
Assay Kits SEA424Hu ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA424Mu01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
RPA424Mu02 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA424Mu01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
PAA424Mu02 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
Assay Kits SEA424Mu ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA424Ra01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA424Ra01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Octamer Binding Transcription Factor 4 (OCT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) ELISA Kit Customized Service Offer

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPA424Bo01 Recombinant Octamer Binding Transcription Factor 4 (OCT4) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAA424Bo01 Polyclonal Antibody to Octamer Binding Transcription Factor 4 (OCT4) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Octamer Binding Transcription Factor 4 (OCT4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Octamer Binding Transcription Factor 4 (OCT4) ELISA Kit Customized Service Offer
  1. "Human Oct3 gene family: cDNA sequences, alternative splicing, gene organization, chromosomal location, and expression at low levels in adult tissues."Nucleic Acids Res. 20:4613-4620(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Comparison of MHC class I risk haplotypes in Thai and Caucasian psoriatics shows locus heterogeneity at PSORS1."Tissue Antigens 76:387-397(2010) [PubMed] [Europe PMC] [Abstract]
  3. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity." Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A human POU domain gene, mPOU, is expressed in developing brain and specific adult tissues."Eur. J. Biochem. 220:753-762(1994) [PubMed] [Europe PMC] [Abstract]
  7. "Expression of transcription regulating genes in human preimplantation embryos."Hum. Reprod. 10:2787-2792(1995) [PubMed] [Europe PMC] [Abstract]
  8. "Oct4 pseudogenes are transcribed in cancers."Biochem. Biophys. Res. Commun. 337:1047-1051(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Induction of pluripotent stem cells from adult human fibroblasts by defined factors."Cell 131:861-872(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Pyruvate kinase isozyme type M2 (PKM2) interacts and cooperates with Oct-4 in regulating transcription."Int. J. Biochem. Cell Biol. 40:1043-1054(2008) [PubMed] [Europe PMC] [Abstract]
  11. "WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells."Cell Res. 19:561-573(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Serine 111 phosphorylation regulates OCT4A protein subcellular distribution and degradation."J. Biol. Chem. 287:38279-38288(2012) [PubMed] [Europe PMC] [Abstract]
  13. "Phosphorylation regulates human OCT4."Proc. Natl. Acad. Sci. U.S.A. 109:7162-7168(2012) [PubMed] [Europe PMC] [Abstract]