Heat Shock Protein 60 (Hsp60)
[Edit]HSPD1; GROEL; CPN60; HuCHA60; Heat Shock 60kD Protein 1, Chaperonin; Spastic Paraplegia 13,Autosomal Dominant; 60 kDa chaperonin; Mitochondrial matrix protein P1; P60 lymphocyte protein
In control subjects no significant expression of IFN-γ or interleukin 4 was induced. These results suggest that periodontitis patients have human hsp60-reactive T cells with a type 1 cytokine profile in their peripheral blood T-cell pools.Heat shock protein 60 (HSP60) is homologous to HSP65 (a major antigenic mycobacterial protein) and E. coli GroEL. HSP60, also referred to as chaperonin-60, P1 and mitonin, has been classified as a member of a family of proteins termed chaperonins which act to recognize and stabilize polypeptide intermediates during folding, assembly and disassembly. HSP60 is an abundant protein which is constitutively expressed and is induced by environmental stress. HSP60 exists as a large oligomer composed of 14 ~60 kDa subunits arranged as two stacked rings.
Organism species: Homo sapiens (Human)
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA822Mu01 | Recombinant Heat Shock Protein 60 (Hsp60) | Positive Control; Immunogen; SDS-PAGE; WB. |
RPA822Mu02 | Recombinant Heat Shock Protein 60 (Hsp60) | Positive Control; Immunogen; SDS-PAGE; WB. | |
Antibodies | PAA822Mu01 | Polyclonal Antibody to Heat Shock Protein 60 (Hsp60) | WB; IHC; ICC; IP. |
PAA822Mu02 | Polyclonal Antibody to Heat Shock Protein 60 (Hsp60) | WB; IHC; ICC; IP. | |
Assay Kits | SEA822Mu | ELISA Kit for Heat Shock Protein 60 (Hsp60) | Enzyme-linked immunosorbent assay for Antigen Detection. |
SCA822Mu | CLIA Kit for Heat Shock Protein 60 (Hsp60) | Chemiluminescent immunoassay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA822Ra01 | Recombinant Heat Shock Protein 60 (Hsp60) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA822Ra01 | Polyclonal Antibody to Heat Shock Protein 60 (Hsp60) | WB; IHC; ICC; IP. |
MAA822Ra21 | Monoclonal Antibody to Heat Shock Protein 60 (Hsp60) | WB; IHC; ICC; IP. | |
Assay Kits | SEA822Ra | ELISA Kit for Heat Shock Protein 60 (Hsp60) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Oryctolagus cuniculus (Rabbit)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant Heat Shock Protein 60 (Hsp60) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to Heat Shock Protein 60 (Hsp60) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to Heat Shock Protein 60 (Hsp60) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | SEA822Rb | ELISA Kit for Heat Shock Protein 60 (Hsp60) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Chicken (Gallus)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPA822Ga01 | Recombinant Heat Shock Protein 60 (Hsp60) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAA822Ga01 | Polyclonal Antibody to Heat Shock Protein 60 (Hsp60) | WB; IHC; ICC; IP. |
Assay Kits | n/a | CLIA Kit for Heat Shock Protein 60 (Hsp60) | CLIA Kit Customized Service Offer |
n/a | ELISA Kit for Heat Shock Protein 60 (Hsp60) | ELISA Kit Customized Service Offer |
- "Primary structure of a human mitochondrial protein homologous to the bacterial and plant chaperonins and to the 65-kilodalton mycobacterial antigen."Mol. Cell. Biol. 9:2279-2283(1989) [PubMed] [Europe PMC] [Abstract]
- "Nucleotide sequences and novel structural features of human and Chinese hamster hsp60 (chaperonin) gene families."DNA Cell Biol. 9:545-552(1990) [PubMed] [Europe PMC] [Abstract]
- "Genomic structure of the human mitochondrial chaperonin genes: HSP60 and HSP10 are localised head to head on chromosome 2 separated by a bidirectional promoter."Hum. Genet. 112:71-77(2003) [PubMed] [Europe PMC] [Abstract]
- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
- "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
- "Amino-acid sequence homology of a polymorphic cellular protein from human lymphocytes and the chaperonins from Escherichia coli (groEL) and chloroplasts (Rubisco-binding protein)."Biol. Chem. Hoppe-Seyler 369:1185-1189(1988) [PubMed] [Europe PMC] [Abstract]
- "Development of a database of amino acid sequences for human colon carcinoma proteins separated by two-dimensional polyacrylamide gel electrophoresis."Electrophoresis 11:883-891(1990) [PubMed] [Europe PMC] [Abstract]
- "Complex formation of human T-cell leukemia virus type I p40tax transactivator with cellular polypeptides."J. Virol. 66:1040-1049(1992) [PubMed] [Europe PMC] [Abstract]
- "Two-dimensional electrophoretic analysis of human breast carcinoma proteins: mapping of proteins that bind to the SH3 domain of mixed lineage kinase MLK2."Electrophoresis 18:588-598(1997) [PubMed] [Europe PMC] [Abstract]
- "The human myocardial two-dimensional gel protein database: update 1994."Electrophoresis 15:1459-1465(1994) [PubMed] [Europe PMC] [Abstract]
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
- "Human liver protein map: a reference database established by microsequencing and gel comparison."Electrophoresis 13:992-1001(1992) [PubMed] [Europe PMC] [Abstract]