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Proteinase 3 (PR3)

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MBN; PRTN3; ACPA; AGP7; C-ANCA; MBT; P29; PRK; Myeloblastin; Serine Proteinase,Neutrophil,Wegener Granulomatosis Autoantigen

Proteinase 3 (PR3)
CCC B434
HGNC 9495
MGI 893580
PubMed 11272267
RGD 1304898
UniProt P24158
Wiki Proteinase_3

PRTN3 is a serine protease enzyme expressed mainly in neutrophil granulocytes. Its exact role in the function of the neutrophil is unknown but in human neutrophils proteinase 3 contributes to the proteolytic generation of antimicrobial peptides. It is also the epitope of anti-neutrophil cytoplasmic antibodies (ANCAs) of the cANCA (cytoplasmic subtype) class, a type of antibody frequently found in the disease Wegener's granulomatosis.

Proteinase K is commonly used in molecular biology to digest protein and remove contamination from preparations of nucleic acid. Addition of proteinase K to nucleic acid preparations rapidly inactivates nucleases that might otherwise degrade the DNA or RNA during purification.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB434Hu01 Recombinant Proteinase 3 (PR3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB434Hu02 Recombinant Proteinase 3 (PR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB434Hu01 Polyclonal Antibody to Proteinase 3 (PR3) WB; IHC; ICC; IP.
MAB434Hu22 Monoclonal Antibody to Proteinase 3 (PR3) WB; IHC; ICC; IP.
PAB434Hu02 Polyclonal Antibody to Proteinase 3 (PR3) WB; IHC; ICC; IP.
Assay Kits SEB434Hu ELISA Kit for Proteinase 3 (PR3) Enzyme-linked immunosorbent assay for Antigen Detection.
AEB434Hu ELISA Kit for Anti-Proteinase 3 Antibody (Anti-PR3) Enzyme-linked immunosorbent assay for Antibody Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB434Mu01 Recombinant Proteinase 3 (PR3) Positive Control; Immunogen; SDS-PAGE; WB.
RPB434Mu02 Recombinant Proteinase 3 (PR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB434Mu01 Polyclonal Antibody to Proteinase 3 (PR3) WB; IHC; ICC; IP.
LAB434Mu71 Biotin-Linked Polyclonal Antibody to Proteinase 3 (PR3) WB; IHC; ICC.
PAB434Mu02 Polyclonal Antibody to Proteinase 3 (PR3) WB; IHC; ICC; IP.
Assay Kits SEB434Mu ELISA Kit for Proteinase 3 (PR3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB434Ra01 Recombinant Proteinase 3 (PR3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB434Ra01 Polyclonal Antibody to Proteinase 3 (PR3) WB; IHC; ICC; IP.
LAB434Ra71 Biotin-Linked Polyclonal Antibody to Proteinase 3 (PR3) WB; IHC; ICC.
MAB434Ra21 Monoclonal Antibody to Proteinase 3 (PR3) WB; IHC; ICC; IP.
Assay Kits SEB434Ra ELISA Kit for Proteinase 3 (PR3) Enzyme-linked immunosorbent assay for Antigen Detection.
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