≡

Tyrosine Hydroxylase (TH)

[Edit]

TYH; DYT5b; Tyrosine 3-Monooxygenase; Dystonia 14

Tyrosine Hydroxylase (TH)
CCC B438
HGNC 11782
MGI 98735
PubMed 15569247
RGD 3853
UniProt P07101
Wiki TH

Tyrosine hydroxylase or tyrosine 3-monooxygenase is the enzyme responsible for catalyzing the conversion of the amino acid L-tyrosine to dihydroxyphenylalanine (DOPA). DOPA is a precursor for dopamine which in turn is a precursor for norepinephrine (noradrenaline) and epinephrine (adrenaline).

In humans, tyrosine hydroxylase is encoded by the TH gene.The enzyme, an oxygenase, is found in the cytosol of all cells containing catecholamines. This initial reaction is the rate limiting step in the production of catecholamines.The enzyme is highly specific, not accepting indole derivatives - which is unusual as many other enzymes involved in the production of catecholamines do.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB438Hu01 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB438Hu01 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu22 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu21 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu24 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu25 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
Assay Kits SEB438Hu ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB438Mi ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB438Mu01 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
RPB438Mu02 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB438Mu01 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
PAB438Mu02 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
Assay Kits SEB438Mi ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.
SEB438Mu ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB438Ra01 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB438Ra01 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
LAB438Ra71 Biotin-Linked Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC.
MAB438Ra21 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Ra22 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Ra27 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Ra23 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Ra24 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Ra25 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
Assay Kits SEB438Ra ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.
SCB438Ra CLIA Kit for Tyrosine Hydroxylase (TH) Chemiluminescent immunoassay for Antigen Detection.
SEB438Mi ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Bos taurus; Bovine (Cattle)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPB438Bo01 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAB438Bo01 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Tyrosine Hydroxylase (TH) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tyrosine Hydroxylase (TH) ELISA Kit Customized Service Offer
  1. "Isolation of a novel cDNA clone for human tyrosine hydroxylase: alternative RNA splicing produces four kinds of mRNA from a single gene."Biochem. Biophys. Res. Commun. 146:971-975(1987) [PubMed] [Europe PMC] [Abstract]
  2. "A single human gene encoding multiple tyrosine hydroxylases with different predicted functional characteristics."Nature 326:707-711(1987) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation of a full-length cDNA clone encoding human tyrosine hydroxylase type 3."Nucleic Acids Res. 15:6733-6733(1987) [PubMed] [Europe PMC] [Abstract]
  4. "Structure of the human tyrosine hydroxylase gene: alternative splicing from a single gene accounts for generation of four mRNA types."J. Biochem. 103:907-912(1988) [PubMed] [Europe PMC] [Abstract]
  5. "Characterisation of novel splicing variants of the tyrosine hydroxylase C-terminal domain in human neuroblastic tumours."Biol. Chem. 388:419-426(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of the 5' region of the human tyrosine hydroxylase gene: combinatorial patterns of exon splicing generate multiple regulated tyrosine hydroxylase isoforms."J. Neurochem. 50:988-991(1988) [PubMed] [Europe PMC] [Abstract]
  9. "Expression of human tyrosine hydroxylase cDNA in invertebrate cells using a baculovirus vector."J. Biol. Chem. 263:7406-7410(1988) [PubMed] [Europe PMC] [Abstract]
  10. "Phosphorylation of human recombinant tyrosine hydroxylase isoforms 1 and 2: an additional phosphorylated residue in isoform 2, generated through alternative splicing."J. Biol. Chem. 266:17124-17130(1991) [PubMed] [Europe PMC] [Abstract]
  11. "A rare novel deletion of the tyrosine hydroxylase gene in Parkinson disease."Hum. Mutat. 31:E1767-E1771(2010) [PubMed] [Europe PMC] [Abstract]
  12. "A point mutation in the tyrosine hydroxylase gene associated with Segawa's syndrome."Hum. Genet. 95:123-125(1995) [PubMed] [Europe PMC] [Abstract]
  13. "Frequent sequence variant in the human tyrosine hydroxylase gene."Hum. Genet. 95:716-716(1995) [PubMed] [Europe PMC] [Abstract]
  14. "Recessively inherited L-DOPA-responsive dystonia caused by a point mutation (Q381K) in the tyrosine hydroxylase gene."Hum. Mol. Genet. 4:1209-1212(1995) [PubMed] [Europe PMC] [Abstract]
  15. "Recessively inherited L-DOPA-responsive parkinsonism in infancy caused by a point mutation (L205P) in the tyrosine hydroxylase gene."Hum. Mol. Genet. 5:1023-1028(1996) [PubMed] [Europe PMC] [Abstract]
  16. "Association study of structural mutations of the tyrosine hydroxylase gene with schizophrenia and Parkinson's disease."Am. J. Med. Genet. 81:131-133(1998) [PubMed] [Europe PMC] [Abstract]
  17. "Systematic search for variations in the tyrosine hydroxylase gene and their associations with schizophrenia, affective disorders, and alcoholism."Am. J. Med. Genet. 81:388-396(1998) [PubMed] [Europe PMC] [Abstract]
  18. "A common point mutation in the tyrosine hydroxylase gene in autosomal recessive L-DOPA-responsive dystonia in the Dutch population."Hum. Genet. 102:644-646(1998) [PubMed] [Europe PMC] [Abstract]
  19. "Biochemical and molecular genetic characteristics of the severe form of tyrosine hydroxylase deficiency."Clin. Chem. 45:2073-2078(1999) [PubMed] [Europe PMC] [Abstract]
  20. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  21. ErratumNat. Genet. 23:373-373(1999)
  22. "Four novel mutations in the tyrosine hydroxylase gene in patients with infantile parkinsonism."Ann. Hum. Genet. 64:25-31(2000) [PubMed] [Europe PMC] [Abstract]
  23. "Tyrosine hydroxylase deficiency unresponsive to L-dopa treatment with unusual clinical and biochemical presentation."J. Inherit. Metab. Dis. 23:819-825(2000) [PubMed] [Europe PMC] [Abstract]
  24. "Long-term course of L-dopa-responsive dystonia caused by tyrosine hydroxylase deficiency."Neurology 63:1524-1526(2004) [PubMed] [Europe PMC] [Abstract]
  25. "Levodopa-responsive infantile parkinsonism due to a novel mutation in the tyrosine hydroxylase gene and exacerbation by viral infections."Mov. Disord. 20:764-767(2005) [PubMed] [Europe PMC] [Abstract]
  26. "Pre- and postnatal diagnosis of tyrosine hydroxylase deficiency."Prenat. Diagn. 25:671-675(2005) [PubMed] [Europe PMC] [Abstract]
  27. "Mutations in the cyclic adenosine monophosphate response element of the tyrosine hydroxylase gene."Ann. Neurol. 62:422-426(2007) [PubMed] [Europe PMC] [Abstract]
  28. "Tyrosine hydroxylase deficiency presenting with a biphasic clinical course."Neuropediatrics 38:213-215(2007) [PubMed] [Europe PMC] [Abstract]
  29. "Molecular analyses of GCH-1, TH and parkin genes in Chinese dopa-responsive dystonia families."Clin. Genet. 74:513-521(2008) [PubMed] [Europe PMC] [Abstract]
  30. "Exhaustive analysis of BH4 and dopamine biosynthesis genes in patients with Dopa-responsive dystonia." Brain 132:1753-1763(2009) [PubMed] [Europe PMC] [Abstract]
  31. "Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis." Brain 133:1810-1822(2010) [PubMed] [Europe PMC] [Abstract]
  32. "Biochemical and molecular characterization of tyrosine hydroxylase deficiency in Hong Kong Chinese."Mol. Genet. Metab. 99:431-433(2010) [PubMed] [Europe PMC] [Abstract]
  33. "A novel compound heterozygous tyrosine hydroxylase mutation (p.R441P) with complex phenotype."J. Parkinson's Dis. 1:119-122(2011) [PubMed] [Europe PMC] [Abstract]
  34. "A new tyrosine hydroxylase genotype associated with early-onset severe encephalopathy."J. Child Neurol. 27:523-525(2012) [PubMed] [Europe PMC] [Abstract]
  35. "Myoclonus-dystonia syndrome due to tyrosine hydroxylase deficiency."Neurology 79:435-441(2012) [PubMed] [Europe PMC] [Abstract]
  36. "Tyrosine hydroxylase deficiency in Taiwanese infants."Pediatr. Neurol. 46:77-82(2012) [PubMed] [Europe PMC] [Abstract]
  37. "GTP cyclohydrolase I and tyrosine hydroxylase gene mutations in familial and sporadic dopa-responsive dystonia patients."PLoS ONE 8:E65215-E65215(2013) [PubMed] [Europe PMC] [Abstract]
  38. "Functional studies of tyrosine hydroxylase missense variants reveal distinct patterns of molecular defects in Dopa-responsive dystonia."Hum. Mutat. 35:880-890(2014) [PubMed] [Europe PMC] [Abstract]