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Recombinant Tyrosine Hydroxylase (TH)

TYH; DYT5b; Tyrosine 3-Monooxygenase; Dystonia 14

  • Product No.RPB438Hu01
  • Organism SpeciesHomo sapiens (Human) Same name, Different species.
  • SourceProkaryotic expression
  • HostE.coli
  • Endotoxin Level<1.0EU per 1µg (determined by the LAL method)
  • Subcellular LocationSecreted
  • Predicted Molecular Mass30.0kDa
  • Accurate Molecular Mass30kDa(Analysis of differences refer to the manual)
  • Residues & TagsLeu82~Cys310 with N-terminal His Tag
  • Buffer Formulation100mMNaHCO3, 500mMNaCl, pH8.3, containing 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose and Proclin300.
  • Traits Freeze-dried powder
  • Purity> 90%
  • Isoelectric Point9.1
  • Applications Positive Control; Immunogen; SDS-PAGE; WB.
    If bio-activity of the protein is needed, please check active protein.
  • DownloadInstruction Manual
  • UOM 10µg50µg 200µg 1mg 5mg
  • FOB US$ 174  US$ 436  US$ 872  US$ 2616  US$ 6540 
    For more details, please contact local distributors!

SEQUENCE

USAGE

Reconstitute in ddH2O to a concentration of 0.1-1.0 mg/mL. Do not vortex.

STORAGE

Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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Magazine Citations
Mol Neurobiol. 1, 25-dyhydroxyvitamin D3 Attenuates l-DOPA-Induced Neurotoxicity in Neural Stem Cells Pubmed:25102940
PLOS ONE Genetic Diagnosis of Two Dopa-Responsive Dystonia Families by Exome Sequencing Pubmed:25181484
biomedicine & pharmacotherapy Acetyl-l-carnitine protects dopaminergic nigrostriatal pathway in 6-hydroxydopamine-induced model of Parkinson's disease in the rat. pubmed:28199883
Therapeutics and Clinical Risk Management Elevated blood plasma levels of epinephrine, norepinephrine, tyrosine hydroxylase, TGFβ1, and TNFα associated with high-altitude pulmonary edema in an Indian population. pubmed:27540296
Sci Rep.  Silencing salusin-β attenuates cardiovascular remodeling and hypertension in spontaneously hypertensive rats. pubmed:28230187
Journal of Cellular Biochemistry Vaccarin administration ameliorates hypertension and cardiovascular remodeling in renovascular hypertensive rats pubmed:28681939
Environmental Science & Technology Multigenerational disruption of the thyroid endocrine system in marine medaka after a life-cycle exposure to perfluorobutanesulfonate Pubmed:29565584
Molecular Neurobiology Cilostazol Mediated Nurr1 and Autophagy Enhancement: Neuroprotective Activity in Rat Rotenone PD Model Pubmed:29429051
Chemosphere Tetrabromobisphenol A caused neurodevelopmental toxicity via disrupting thyroid hormones in zebrafish larvae Pubmed:29407805
Neurospine The Effect of Recombinant Tyrosine Hydroxylase Expression on the Neurogenic Differentiation Potency of Mesenchymal Stem Cells Pubmed:29656620
Toxicology and Applied Pharmacology Montelukast attenuates rotenone-induced microglial activation/p38 MAPK expression in rats: Possible role of its antioxidant, anti-inflammatory and antiapoptotic effects Pubmed: 30222980
International Journal Of Cardiology Silencing salusin β ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK/NF-κB pathways in the paraventricular nucleus Pubmed: 30581101
Behavioural Brain Research Hydroxychloroquine antiparkinsonian potential: Nurr1 modulation versus autophagy inhibition
Environment International Perfluoropolyether carboxylic acids (novel alternatives to PFOA) impair zebrafish posterior swim bladder development via thyroid hormone disruption Pubmed: 31733528
Environmental Pollution Embryonic exposure to pentabromobenzene inhibited the inflation of posterior swim bladder in zebrafish larvae Pubmed: 31935612
International Journal of Pharmacology Nose to brain delivery of rotigotine loaded chitosan nanoparticles in human SH-SY5Y neuroblastoma cells and animal model of Parkinson's disease Pubmed: 32084576
comparative biochemistry and physiology c-toxicology & pharmacology Thyroid disruption and developmental toxicity caused by Cd2+ in Schizopygopsis younghusbandi larvae Pubmed: 32344129
International Journal of Stem cell Research & Therapy Selection of Cells for Parkinson's Disease Cell-Therapy
Ecotoxicol Environ Saf Effects of SiO2 nanoparticles on the uptake of tetrabromobisphenol A and its impact on the thyroid endocrine system in zebrafish larvae 33385677
Nutr Res Tocotrienols protect differentiated SH-SY5Y human neuroblastoma cells against 6-hydroxydopamine-induced cytotoxicity by ameliorating dopamine biosynthesis and … Pubmed:35065349
Food Chem Toxicol Omarigliptin attenuates rotenone-induced Parkinson's disease in rats: Possible role of oxidative stress, endoplasmic reticulum stress and immune modulation Pubmed:35439590
Food Chemistry: Molecular Sciences Unravelling the neuroprotective mechanisms of carotenes in differentiated human neural cells: biochemical and proteomic approaches Pubmed:35415676
Journal of Environmental Sciences Parental and transgenerational impairments of thyroid endocrine system in zebrafish by 2, 4, 6-tribromophenol
Catalog No. Related products for research use of Homo sapiens (Human) Organism species Applications (RESEARCH USE ONLY!)
RPB438Hu01 Recombinant Tyrosine Hydroxylase (TH) Positive Control; Immunogen; SDS-PAGE; WB.
PAB438Hu01 Polyclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu21 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu24 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu25 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
MAB438Hu22 Monoclonal Antibody to Tyrosine Hydroxylase (TH) WB; IHC; ICC; IP.
SEB438Hu ELISA Kit for Tyrosine Hydroxylase (TH) Enzyme-linked immunosorbent assay for Antigen Detection.
LMB438Hu Multiplex Assay Kit for Tyrosine Hydroxylase (TH) ,etc. by FLIA (Flow Luminescence Immunoassay) FLIA Kit for Antigen Detection.
KSB438Hu01 ELISA Kit DIY Materials for Tyrosine Hydroxylase (TH) Main materials for "Do It (ELISA Kit) Yourself".