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Serotonin Transporter (SERT)

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SLC6A4; SLC6-A4; HTT; 5-HTT; 5HTT; OCD1; hSERT; Solute Carrier Family 6,Member 4; Neurotransmitter Transporter,Serotonin; Sodium-dependent serotonin transporter

Serotonin Transporter (SERT)
CCC C890
HGNC 11050
MGI 96285
PubMed 20729489
RGD 3714
UniProt P31645
Wiki SERT
The serotonin transporter (SERT) is a monoamine transporter protein.This protein is an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. This transport of serotonin by the SERT protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamine, cocaine, and MDMA, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, post-traumatic stress disorder and depression-susceptibility in people experiencing emotional trauma.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC890Hu01 Recombinant Serotonin Transporter (SERT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC890Hu01 Polyclonal Antibody to Serotonin Transporter (SERT) WB; IHC; ICC; IP.
MAC890Hu22 Monoclonal Antibody to Serotonin Transporter (SERT) WB; IHC; ICC; IP.
MAC890Hu21 Monoclonal Antibody to Serotonin Transporter (SERT) WB; IHC; ICC; IP.
Assay Kits SEC890Hu ELISA Kit for Serotonin Transporter (SERT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC890Mu01 Recombinant Serotonin Transporter (SERT) Positive Control; Immunogen; SDS-PAGE; WB.
RPC890Mu02 Recombinant Serotonin Transporter (SERT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC890Mu01 Polyclonal Antibody to Serotonin Transporter (SERT) WB; IHC; ICC; IP.
PAC890Mu02 Polyclonal Antibody to Serotonin Transporter (SERT) WB; IHC; ICC; IP.
Assay Kits SEC890Mu ELISA Kit for Serotonin Transporter (SERT) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPC890Ra01 Recombinant Serotonin Transporter (SERT) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAC890Ra01 Polyclonal Antibody to Serotonin Transporter (SERT) WB; IHC; ICC; IP.
MAC890Ra21 Monoclonal Antibody to Serotonin Transporter (SERT) WB; IHC; ICC; IP.
Assay Kits SEC890Ra ELISA Kit for Serotonin Transporter (SERT) Enzyme-linked immunosorbent assay for Antigen Detection.
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  11. "Serotonin transamidates Rab4 and facilitates its binding to the C terminus of serotonin transporter."J. Biol. Chem. 283:9388-9398(2008) [PubMed] [Europe PMC] [Abstract]
  12. "The cellular distribution of serotonin transporter is impeded on serotonin-altered vimentin network."PLoS ONE 4:E4730-E4730(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Tyrosine phosphorylation of the human serotonin transporter: a role in the transporter stability and function."Mol. Pharmacol. 81:73-85(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Characterization of single-nucleotide polymorphisms in coding regions of human genes."Nat. Genet. 22:231-238(1999) [PubMed] [Europe PMC] [Abstract]
  15. ErratumNat. Genet. 23:373-373(1999)
  16. "Serotonin transporter missense mutation associated with a complex neuropsychiatric phenotype."Mol. Psychiatry 8:933-936(2003) [PubMed] [Europe PMC] [Abstract]
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  18. "Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene."Science 301:386-389(2003) [PubMed] [Europe PMC] [Abstract]
  19. "Meta-analysis of the association of a functional serotonin transporter promoter polymorphism with alcohol dependence."Am. J. Med. Genet. B Neuropsychiatr. Genet. 133:79-84(2005) [PubMed] [Europe PMC] [Abstract]