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Rat Model for Tourette Syndrome (TS)

Tourette's

  • Product No.DSI550Ra01
  • Organism SpeciesRattus norvegicus (Rat) Same name, Different species.
  • Prototype SpeciesHuman
  • SourceInduced by 3,3 '-iminodipropionitrile(IDPN)
  • Model Animal StrainsSD Rats(SPF), healthy, male, bodyweight:180g~200g
  • Modeling GroupingRandomly divided into six group: Control group, Model group, Positive drug group (Tiapride Hydrochloride )and Test drug group (three doses) n=15.
  • Modeling Period7d
  • Modeling Method1. The rats were injected intraperitoneally with  3,3 '-iminodipropionitrile(IDPN), and the dose: 300 mg/(kg.d) for continuous administration for 7 days.
    2. After modeling, the rats were given intragastric administration at the same time every morning. The blank group and model group were given normal saline. The intragastric dose was 1mL/100g.
  • ApplicationsUsed to screen drugs for preventing and treatment for Tourette Syndrome
  • Downloadn/a
  • UOM Each case
  • FOB US$ 200 
    For more details, please contact local distributors!

Model Evaluation

Behavioral experiment evaluation criteria
1. Motion behavior assessment standard:
0 points: quiet or normal activity;
1 points: over excited;
2 points: increase the behavior of inquiry, non continuous nasal suction;
3 points: keep running;
4 points: stop running with startle.
2. Stereotyped behavior assessment standard: according to the Diamond score
0 points: no stereotyped movement;
1 points: the body rotation behavior (rotation clockwise or counterclockwise);
2 points: head and neck movement up and down too much (an abnormal movement of head and neck and vertical direction);
3 points: head and neck movement up and down too much and rotating motion;
4 points: head to the side of the pendulum, with head and neck movement up and down too much.

Behavioral assessment time: the behavioral experiment was performed every other day for 7 days after modeling, and a total of 5 behavioral tests were performed.

Pathological Results

Cytokines Level

Dopamine(DA), Dopamine receptor 2(D2R):
After the last administration of fasting but free drinking water at night, 5 rats in each group were randomly selected, after the end of the blood into the EDTA anticoagulant tube, frozen centrifugation (3000 rpm, 10 minutes), take the supernatant stored at -80℃.
ELISA kit was used to detect the content of DA and D2R in serum and striatum

Statistical Analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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Catalog No. Related products for research use of Rattus norvegicus (Rat) Organism species Applications (RESEARCH USE ONLY!)
DSI550Ra01 Rat Model for Tourette Syndrome (TS) Used to screen drugs for preventing and treatment for Tourette Syndrome