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Rat Model for Withdrawal Syndrome (WS)

Discontinuation syndrome

Model Evaluation

Alcohol withdrawal after 24h, the rats were sacrificed, the brain, the content changes of cerebral cortex in p-CREB and BDNF were detected by QPCR method, the results show that the alcohol withdrawal 24h in the cerebral cortex p-CREB, BDNF decreased significantly.

Pathological Results

Cytokines Level

Statistical Analysis

SPSS software is used for statistical analysis, measurement data to mean ± standard deviation (x ±ｓ), using t test and single factor analysis of variance for group comparison, P<0.05 indicates there was a significant difference, P<0.01 indicates there are very significant differences.

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DSI834Ra01 Rat Model for Withdrawal Syndrome (WS) Disease Model