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Monoclonal Antibody to Collagen Type IV Alpha 1 (COL4a1)

COL4-A1; Arresten; Collagen Alpha-1(IV)chain

SPECIFITY

The antibody is a mouse monoclonal antibody raised against COL4a1. It has been selected for its ability to recognize COL4a1 in immunohistochemical staining and western blotting.

USAGE

Western blotting: 0.01-2µg/mL;
Immunohistochemistry: 5-20µg/mL;
Immunocytochemistry: 5-20µg/mL;
Optimal working dilutions must be determined by end user.

STORAGE

Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.

STABILITY

The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.

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INCREMENT SERVICES

Magazine Citations
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PLoS One miR-146a regulates glucose induced upregulation of inflammatory cytokines extracellular matrix proteins in the retina and kidney in diabetes 10.1371
Journal of Diabetes & Metabolic Disorders Endothelin-1 traps potently reduce pathologic markers back to basal levels in an in vitro model of diabetes
Experimental and Molecular Pathology  Epitope recognized by anti-glomerular basement membrane (GBM) antibody in a patient with repeated relapse of anti-GBM disease Pubmed: 30817909
Journal of Diabetes & Metabolic Disorders In vivo studies demonstrate that endothelin-1 traps are a potential therapy for type I diabetes
Frontiers in Endocrinology Curcumin Analogs Reduce Stress and Inflammation Indices in Experimental Models of Diabetes Pubmed: 31920992
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