On 12 October,2022, Linhu Ge, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Guangzhou Key Laboratory of Basic and Applied Research of Oral Regenerative Medicine, China, and his team published a paper titled “SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis” in Journal of Advanced Research. They showed that SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of P. gingivalis.The kits [ELISA Kit for Serum Amyloid P Component (SAP), SE......2022-12-03

On Oct 24, 2022, professor Tiebang Kang from Sun Yat-sen University Cancer Center published a paper titled Intercellular transfer of activated STING triggered by RAB22A-mediated non-canonical autophagy promotes antitumor immunity on Cell Research.STING, an endoplasmic reticulum (ER) transmembrane protein, mediates innate immune activation upon cGAMP stimulation and is degraded through autophagy. Here, we report that activated STING could be transferred between cells to promote antitumor immunity, a process triggered by RAB22A-mediated non-canonical autophagy. Mechanistically, RAB22A engages PI4K2A to generate PI4P that recruits the Atg12–Atg5–Atg16L1 complex, inducing the formation......2022-12-03

The International Association for the Study of Pain (IASP) Task Force recently proposed a new definition of pain as an aversive sensory and emotional experience typically caused by, or resembling that caused by, actual or potential tissue injury. Importantly, acute pain serves a critical Darwinian protective function: to initiate an escape response from noxious stimuli that in the future should be avoided for personal safety. However, chronic intractable pain is maladaptive and constitutes a widespread public health issue, significantly impairing quality of life. Pain may arise from multiple mechanisms, and this complexity reflects the difficulty in achieving significant relief. Recent......2022-11-25

On September 30, 2022,Qiujing Yu, Division of Infectious Disease, Second Hospital of Tianjin Medical University, China, and his team published a paper titled “Serine metabolism orchestrates macrophage polarization by regulating the IGF1–p38 axis” in Cellular & Molecular Immunology. Their findings clarify a previously unknown mechanism by which serine metabolism plays a key role in orchestrating macrophage polarization.The kits[ELISA Kit for S-Adenosyl Methionine (SAM), CEG414Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Serine metabolism is reportedly involved in immune cell functions, but whether and how serine metabolism reg......2022-11-23

Bacteriophages (phages) are viruses that selectively infect bacteria. Phages can be biologically active within bodies, infecting and subsequently killing and lysing bodyassociated bacteria, and the application of phages to bodies to combat bacterial infections is called phage therapy. However, the discovery of antibiotics, subsequent large-scale industrial production, and wide clinical application have caused phage therapy to become unfavorable. In recent years, phage therapy has been re-emphasized as the severity of drug-resistant bacterial infections has increased. Indeed, phages alone or combined with antibiotics have been successfully used to treat diferent bacterial infections, in......2022-11-21

On October 19, 2022,Xin Pan, Nanhu Laboratory, National Center of Biomedical Analysis, China, and his team published a paper titled “Glioblastoma stem cell-specific histamine secretion drives pro-angiogenic tumor microenvironment remodeling” in Cell Stem Cell. Their findings established that glioblastoma stem cells (GSCs)-specific metabolite secretion remodels the tumor microenvironment and highlight histamine targeting as a potential strategy for glioblastoma multiforme (GBM) therapy.The antibodies[Polyclonal Antibodyto Histidine Decarboxylase (HDC), PAG476Hu01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.The communication betwee......2022-11-17