On June 29, 2022,N. Altan-Bonnet, Laboratory of Host-Pathogen Dynamics, National Heart Lung and Blood Institute, National Institutes of Health, USA, and his team published a paper titled “Enteric viruses replicate in salivary glands and infect through saliva” in Nature, which uncovered a new transmission route for enteric viruses.The kits [ELISA Kit for Secretory Immunoglobulin A (sIgA), SEA641Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Enteric viruses like norovirus, rotavirus and astrovirus have long been accepted as spreading in the population through fecal–oral transmission: viruses are shed into feces from one host and ......2022-08-05

Malaria is a deadly infectious disease, caused by protist parasites of the genus Plasmodium,that affects 241 million people worldwide. Current antimalarial treatments are rapidly losing efficacy, and standard-of-care artemisinin combination therapies fail to cure infections in ~50% of patients in some regions of Asia. Clinically validated resistance to artemisinins has now been detected in Africa, where most malaria deaths occur. New treatments with novel modes of action are urgently needed to overcome existing resistance, expand possible treatment options, and enable more effective combination therapies. 1. Activation of cGAS-STING by Lethal Malaria N67C Dictates Immunity and Mortalit......2022-08-05

Diabetes is a tremendous health problem worldwide. It is caused by chronic high glucose levels in the blood as a result of the incapability of β cells in the pancreas to produce adequate insulin or ineffective insulin utilization by cells in the body. There are generally 3 types of diabetes: Type I, II and gestationaldiabetes but more emphasis is placed on the first 2 types of diabetes.As a chronic condition, diabetes tends to increase the risk of several other diseases caused by macrovascular and microvascular damage, and it has negative impacts on several organs, such as the brain, kidney, heart, and eyes. In addition, diabetic patients are more susceptible to infection. Recently, a......2022-07-22

On 16 June 2022, Xiangming Mao, Department of Urology, Zhujiang Hospital, Southern Medical University, China, and his team published a paper titled “Gut dysbiosis promotes prostate cancer progression anddocetaxel resistance viaactivating NF-κB-IL6-STAT3 axis” in Microbiome, which demonstrated that gut dysbiosis resulted in the elevation of gut permeability and intratumoral LPS, promoting the development of prostate cancer via the NF-κB-IL6-STAT3 axis in mice.The antibodies [Monoclonal Antibody to Lipopolysaccharide (LPS), MAB526Ge22]and kits [ELISA Kit for Lipopolysaccharide (LPS), SEB526Ge]of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaser......2022-07-20

A Brief Introduction of MonkeypoxRecently, monkeypoxvirus is widespread in west and central Africa, which attracts global attention. The World Health Organization (WHO) statesthat monkeypox constitutes a "moderate risk" to overall public health at the global level after cases were reported in countries, but it is not ruled out that the risk level may be increased with the spread of the virus in future days. Notably, this is the first time monkeypox virus has spread in multiple "non-endemic countries" outside of Central and West Africa, with human-to-human transmission.Like smallpox virus and vaccinia virus, monkeypox virus belongs to the Orthopoxvirus genus, and the......2022-07-18

On 6 June 2022, Jie Na, Center for Stem Cell Biology and Regenerative Medicine, School of Medicine, Tsinghua University, China, and his team published a paper titled “Integrative epigenomic and transcriptomic analysis reveals the requirement of JUNB for hematopoietic fate induction” in Nature Communications.In this study, they found that JUNB is an essential regulator for hemogenic endothelium specialization and endothelial-to-hematopoietic transition.The antibodies [None-Linked Guinea pig Anti-Rabbit IgG Polyclonal Antibody, SAA544Rb50] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Human pluripotent stem cell differentiation toward......2022-07-14