Anxiety disorders are among the most prevalent and disabling psychiatric disorders. The core feature of anxiety disorders is excessive fear and anxiety and related behavioral disturbances.Patients with anxiety disorders experience substantial physical and emotional discomfort and have elevated rates of substance use and medical illnesses.Furthermore, anxiety disorders are characterized by high comorbidity along with other mental disorders (eg, mood, substance-abuse, or personality disorders). Compounding this, response rates to first-line pharmacological and psychological treatments are less than 50%. Recently, several papers have reported anxiety related studies, which may provide hel......2023-05-15

On April 7, 2023, Lingqiang Zhang's team, State Key Laboratory of Proteomics, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, China, and Cui Hua Liu's team, CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, China, published a paper titled “OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2” in Signal Transduction and Targeted Therapy. Their results suggested that OTUB1 positively regulates osteogenic differentiation and mineralization in bone homeostasis by controlling FGFR2 stability.The kits [ELISA Kit for Cross Linked C-Telopeptide Of Type I Collagen (CTX......2023-05-15

2023-04-24

Cancer therapy using monoclonal antibodies (mAbs) is a rapidly developing field, due in large part to naturally favorable attributes such as specificity, potency, and metabolic stability. Most of them act by binding to transmembrane receptors or soluble ligands, thereby interfering with their signal transduction pathways, resulting in inhibition of tumor cell proliferation or angiogenesis. Due to the presence of an intact Fc domain, mAbs can evoke antibody-dependent cell-mediated cytotoxicity by attracting complement or effector cells of the human immune system to the cancer site. mAbs have also been used as targeting moieties for the delivery of nanomedicinesor conjugating to cytotoxi......2023-04-21

On March 14, 2023,Ni Tang, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, China, and his team published a paper titled “Deficiency of gluconeogenic enzyme PCK1 promotes metabolic-associated fatty liver disease through PI3K/AKT/PDGF axis activation in male mice” in Nature Communications. They showed that hepatic PCK1 deficiency may be important in hepatic steatosis and fibrosis development through paracrine secretion of PDGF-AA in male mice.The kits [ELISA Kit for Platelet Derived Growth Factor AA (PDGFAA), SEA523Mu, SEA523Hu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Metabolic as......2023-04-21

Epilepsy occurswhen there is abnormal synchronous neuronal firing in a section of the brain, or throughout the entirety of the brain. In children, the most common causes of epilepsy are genetic, injury due to perinatal insults, and malformations of cortical development. In adults without a genetic predisposition to epilepsy, common etiologies for seizures include encephalitis/meningitis, traumatic brain injury, and brain tumors. In elderly patients, epilepsyis usually the result of primary neurodegenerative disorders, head trauma, and brain tumors. Recently, some papers have reported epilepsy related research, which may provide help for the prevention and treatment of epilepsy.1. Compr......2023-04-18