On 16 February 2022, Yuanyu Huang, Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering, Beijing Institute of Technology, and his team published a paper tittled “Thermostable ionizable lipid-like nanoparticle (iLAND) for RNAi treatment of hyperlipidemia” in SCIENCE ADVANCES, which established a thermostable clinically applicable delivery system for siRNA drug.The protein [Recombinant Calreticulin (CALR), RPB486Ra01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Small interfering RNA (siRNA) therapeutic is considered to be a promising modality for the treatment of hyperlipidemia. Establishment of a thermostable cl......2022-03-10

Lipopolysaccharide (LPS) is the component of the outer wall of gram-negative bacteria cell wall, and it consists of three components: lipid A, core polysaccharide and O-antigen.The lipid A of LPS enters the lipid layer as a component of the outer layer of the lipid bilayer, and the sugar chain is exposed outside the cell, and exists in this form on the cell surface of Gram-negative bacteria. LPS is difficult to come off the cell wall. When bacteria die, it will come off by dissolving and destroying cells, and exert its toxicity by acting on animal cells. Because of this nature, it is not a toxin secreted by bacteria outside the body (exotoxin), but a toxin that does not secrete, so it ......2022-03-10

Parkinson’s disease (PD) is the second most common neurodegenerative disease, affecting millions of individuals. These motor signs are usually preceded by non-motor manifestations such as olfactory dysfunction, rapid eye movement sleep behaviour disorder, depression, and constipation.Additionally, over the course of the disease, cognitive impairment also develops with progression to dementia in up to 80% of the patients. New progress in Parkinson's disease researchThe cardinal motor symptoms of PD are caused by the loss of dopaminergic neurons in the substantia nigra that modulate basal ganglia circuits regulating habitual and goal-directed movement. The pathogenesis of PD is und......2022-03-07

On 27 January 2022, Johannes Keller, Department of Trauma and Orthopedic Surgery, University Medical Center Hamburg-Eppendorf, Germany, and his team published a paper tittled “Procalcitonin is expressed in osteoblasts and limits bone resorption through inhibition of macrophage migration during intermittent PTH treatment” in Bone Research, which revealed a potential role of osteoblast-derived procalcitonin (ProCT) in the bone microenvironment.The Antibody[Polyclonal Antibody to Procalcitonin (PCT), PAA689Mu01] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Intermittent injections of parathyroid hormone (iPTH) are applied clinically to......2022-03-03

Myocardial hypertrophyis a slowly developing compensatory mechanism of cardiac function, which mainly occurs in the case of long-term stress overload. It is manifested as an increase in the total amount of cardiac muscle and a strengthening of its contractility, so that the heart can maintain normal blood circulation.However, this compensatory function also has its disadvantages, mainly because hypertrophy myocardial oxygen demand increases, and coronary artery blood supply often can not be satisfied, resulting in myocardial ischemia, which will eventually lead to the decrease of myocardial contractility.Targeting myocardial hypertrophy in the treatment of heart failureHeart failure (H......2022-02-25

On 6 January 2022, William Ka Kei Wu, Department of Anaesthesia and Intensive Care, The Chinese University of Hong Kong, and his team published a paper tittled “Vitamin D3 and carbamazepine protect against Clostridioides difficile infection in mice by restoring macrophage lysosome acidification”in Autophagy, which showed that Vitamin D3 and carbamazepine protect against Clostridioides difficileinfection (CDI) by restoring melanocyte inducing transcription factor (MITF) expression and lysosomal function in mice.The kits [ELISA Kit for Interleukin 8 (IL8), SEA080Hu; ELISA Kit for Chemokine (C-X-C Motif) Ligand 2 (CXCL2), SEB603Hu/SEB603Mu] of Cloud-Clone brand was chosed in this arti......2022-02-24