Colorectal cancer (CRC) is one of the most common human malignancies accounting for approximately 10% of worldwide cancer incidence and mortality. While early-stage CRC is curable by surgery, treatment of metastatic colorectal cancer (mCRC) remains an unmet clinical need. Moreover, about 25% of CRC cases are diagnosed only at the metastatic stage. Despite the extensive molecular and functional knowledge on this disease, systemic therapy for mCRC still relies on traditional 5-fuorouracil (5-FU)-based chemotherapy regimens. So far, targeted therapies and immunotherapy have shown effectiveness only in a limited subset of CRC patients. Therefore, there is an urgent need to understand the m......2022-07-08

On 23 May 2022, Yiguang Wang, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, China, and Fuping You, Institute of Systems Biomedicine, Department of Immunology, Beijing Key Laboratory of Tumour Systems Biology, Peking University Health Science Center, China, and their team published a paper titled “A pyroptosis nanotuner for cancer therapy” in Nature Nanotechnology, which offers new insights into how to engineer nanomedicines with tunable pyroptosis activity through specific targeting of distinct endocytic signalling for biomedical applications.The kits [ELISA Kit for Inositol Triphosphate (IP3), CEC037Ge] of Cloud-Clone b......2022-07-06

On May 23,2022, professor Yiguang Wang from State Key Laboratory of Natural and Biomimetic Drugs, School of PharmaceuticalSciences,Peking University published a paper titled A pyroptosis nanotumer for cancer therapy on Nature Namotechmology.Pyroptosis is a gasdermin-mediated programmed necrosis that occurs via membrane perforation and that can be exploited for biomed-ical applications in cancer therapy. However, inducing specific pyroptotic cancer cell death while sparing normal cells is challenging.Here, we report an acid-activatable nanophotosensitizer library that can be used to spatiotemporally target distinctstages of endosomalmaturation, cnabling tumnable cellular pyroptosis. Spe......2022-06-27

Central nervous system(CNS)injury is one of the leading causes of death and disability.Although the causes of injury are diverse, the common end result is substantial neuronal damage, or neuronal loss, in the affected region. This is thought to underlie the cognitive, sensorimotor function and personality changes typically seen in patients. To date, drug treatments adopting a ‘neuro-centric’ approach have failed to deliver notable clinical benefits for the treatment of CNS injury. Recently, a number of literatures have reported potential therapeutic methods for brain injury, which may help improve the prognosis of patients with brain injury.1. Astrocyte-targeted gene delivery of IL......2022-06-24

On May 6, 2022, Ching-Hsiu Tsai, Graduate Institute of Biotechnology, National Chung Hsing University, Taiwan, and his team published a paper titled “The gibberellic acid derived from the plastidial MEP pathway is involved in the accumulation of Bamboo mosaic virus” in New Phytologist, which confirmed the de novo synthesis of gibberellic acid could assist BaMV accumulation.The kits [ELISA Kit for Gibberellic Acid (GA), CEA759Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.A gene upregulated in Nicotiana benthamiana after Bamboo mosaic virus (BaMV) infection was revealed as 1-deoxy-D-xylulose-5-phosphate reductoisomerase (NbDXR). D......2022-06-22

Cardiovascular diseases (CVD), including atherosclerosis, hypertension, heart failure, atrial fibrillation and myocardial fibrosis, are associated with high morbidity and mortality. Many risk factors are widely known, such as smoking, poor dietary habits, obesity, diabetes mellitus and high cholesterol, but these cannot explain all CVD incidences. Accumulating evidence has demonstrated that gut microbiome and their metabolites play a pivotal role in the onset and progression of CVD. Recently, several studies have reported the correlation between intestinal microbes and CVD, which may provide help for the prevention and treatment of CVD.1. Interplay between diet and gut microbiome, and ......2022-06-20