A Disintegrin And Metalloprotease 17 (ADAM17)
[Edit]CD156b; TACE; CSVP; Tumor Necrosis Factor,Alpha,Converting Enzyme; Disintegrin and metalloproteinase domain-containing protein 17; Snake venom-like protease
ADAM17 is a 70-kDa enzyme that belongs to the ADAM protein family of disintegrins and metalloproteases. ADAM17 is understood to be involved in the processing of tumor necrosis factor alpha (TNF-alpha;) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. This process, which is also known as 'shedding', involves the cleavage and release of a soluble ectodomain from membrane-bound pro-proteins (such as pro-TNF-alpha;), and is of known physiological importance.
ADAM17 was the first 'sheddase' to be identified, and is also understood to play a role in the release of a diverse variety of membrane-anchored cytokines, cell adhesion molecules, receptors, ligands, and enzymes.
Organism species: Homo sapiens (Human)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB555Hu01 | Recombinant A Disintegrin And Metalloprotease 17 (ADAM17) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB555Hu01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB; IHC; ICC; IP. |
MAB555Hu22 | Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB; IHC | |
LAB555Hu71 | Biotin-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB; IHC; ICC. | |
LAB555Hu81 | FITC-Linked Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB; IHC; ICC; IF. | |
MAB555Hu21 | Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB; IHC; ICC; IP. | |
MAB555Hu24 | Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB | |
MAB555Hu23 | Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB; IHC; ICC; IP. | |
Assay Kits | SEB555Hu | ELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Mus musculus (Mouse)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | n/a | Recombinant A Disintegrin And Metalloprotease 17 (ADAM17) | Recombinant Protein Customized Service Offer |
Antibodies | n/a | Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | Monoclonal Antibody Customized Service Offer |
n/a | Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | Polyclonal Antibody Customized Service Offer | |
Assay Kits | SEB555Mu | ELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
Organism species: Rattus norvegicus (Rat)
CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
Proteins | RPB555Ra01 | Recombinant A Disintegrin And Metalloprotease 17 (ADAM17) | Positive Control; Immunogen; SDS-PAGE; WB. |
Antibodies | PAB555Ra01 | Polyclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB; IHC; ICC; IP. |
MAB555Ra21 | Monoclonal Antibody to A Disintegrin And Metalloprotease 17 (ADAM17) | WB; IHC; ICC; IP. | |
Assay Kits | SEB555Ra | ELISA Kit for A Disintegrin And Metalloprotease 17 (ADAM17) | Enzyme-linked immunosorbent assay for Antigen Detection. |
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- "A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells."Nature 385:729-733(1997) [PubMed] [Europe PMC] [Abstract]
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- "The heterotaxy gene GALNT11 glycosylates Notch to orchestrate cilia type and laterality."Nature 504:456-459(2013) [PubMed] [Europe PMC] [Abstract]
- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein."J. Virol. 88:1293-1307(2014) [PubMed] [Europe PMC] [Abstract]
- "Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme."Proc. Natl. Acad. Sci. U.S.A. 95:3408-3412(1998) [PubMed] [Europe PMC] [Abstract]