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Cytochrome P450 27B1 (CYP27B1)

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VDD1, PDDR; CYP1, P450c1; 25-Hydroxyvitamin D3 1-Alpha-Hydroxylase; Cytochrome P450 Family 27 Subfamily B Polypeptide 1; Calcidiol 1-monooxygenase; VD3 1A hydroxylase

Cytochrome P450 27B1 (CYP27B1)
CCC D539
HGNC 2606
MGI 1098274
PubMed 16549446
RGD 69192
UniProt O15528
Wiki CYP27B1
CYP27B1 isa member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the inner mitochondrial membrane where it hydroxylates 25-hydroxyvitamin D3 at the 1alpha position.
This reaction synthesizes 1alpha,25-dihydroxyvitamin D3, the active form of vitamin D3, which binds to the vitamin D receptor and regulates calcium metabolism. Thus this enzyme regulates the level of biologically active vitamin D and plays an important role in calcium homeostasis. Mutations in this gene can result in vitamin D-dependent rickets type I.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD539Hu01 Recombinant Cytochrome P450 27B1 (CYP27B1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD539Hu01 Polyclonal Antibody to Cytochrome P450 27B1 (CYP27B1) WB; IHC; ICC; IP.
Assay Kits SED539Hu ELISA Kit for Cytochrome P450 27B1 (CYP27B1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD539Mu01 Recombinant Cytochrome P450 27B1 (CYP27B1) Positive Control; Immunogen; SDS-PAGE; WB.
RPD539Mu02 Recombinant Cytochrome P450 27B1 (CYP27B1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD539Mu01 Polyclonal Antibody to Cytochrome P450 27B1 (CYP27B1) WB; IHC; ICC; IP.
PAD539Mu02 Polyclonal Antibody to Cytochrome P450 27B1 (CYP27B1) WB; IHC; ICC; IP.
Assay Kits SED539Mu ELISA Kit for Cytochrome P450 27B1 (CYP27B1) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPD539Ra01 Recombinant Cytochrome P450 27B1 (CYP27B1) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAD539Ra01 Polyclonal Antibody to Cytochrome P450 27B1 (CYP27B1) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Cytochrome P450 27B1 (CYP27B1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Cytochrome P450 27B1 (CYP27B1) ELISA Kit Customized Service Offer
  1. "Complete structure of the human gene for the vitamin D 1alpha-hydroxylase, P450c1alpha."DNA Cell Biol. 16:1499-1507(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase."Biochem. Biophys. Res. Commun. 239:527-533(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning of human 25-hydroxyvitamin D-1 alpha-hydroxylase and mutations causing vitamin D-dependent rickets type 1."Mol. Endocrinol. 11:1961-1970(1997) [PubMed] [Europe PMC] [Abstract]
  4. "Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion."Mol. Cancer Res. 1:56-67(2002) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Inactivating mutations in the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in patients with pseudovitamin D-deficiency rickets."N. Engl. J. Med. 338:653-661(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Genetics of vitamin D 1-alpha-hydroxylase deficiency in 17 families."Am. J. Hum. Genet. 63:1694-1702(1998) [PubMed] [Europe PMC] [Abstract]
  9. "Novel mutations in the 1alpha-hydroxylase (P450c1) gene in three families with pseudovitamin D-deficiency rickets resulting in loss of functional enzyme activity in blood-derived macrophages."J. Bone Miner. Res. 14:730-739(1999) [PubMed] [Europe PMC] [Abstract]
  10. "No enzyme activity of 25-hydroxyvitamin D3 1alpha-hydroxylase gene product in pseudovitamin D deficiency rickets, including that with mild clinical manifestation."J. Clin. Endocrinol. Metab. 84:4111-4117(1999) [PubMed] [Europe PMC] [Abstract]
  11. "Novel gene mutations in patients with 1alpha-hydroxylase deficiency that confer partial enzyme activity in vitro."J. Clin. Endocrinol. Metab. 87:2424-2430(2002) [PubMed] [Europe PMC] [Abstract]