As a lytic and inflammatory type of regulated cell death, pyroptosis is characterized by cell swelling, lysis, and the release of many proinflammatory factors, including IL1β, IL-18, ATP, and HMGB1. Dying cells activate pyroptosis through the following two main approaches: (i) GSDMD (gasdermin D)-dependent activation regulated by caspase 1/4/5/11 and (ii) GSDME-dependent activation regulated by caspase 3. Activated caspases cleave the hinge region between the N- and C-terminal domains of GSDMD or GSDME, releasing the segment with lethal activity and leading to pyroptosis. Few studies investigated the roles of other GSDM family members in pyroptosis, but GSDMA, GSDMB, and GSDMC also ha......2023-06-05

On March 22, 2023,Guanwei Fan, State Key Laboratory of Modern Chinese Medicine, Key Laboratory of Pharmacology of Traditional Chinese Medical Formulae for the Ministry of Education, Tianjin University of Traditional Chinese Medicine, China, and his team published a paper titled “M2 Macrophage-Derived sEV Regulate Pro-Inflammatory CCR2+Macrophage Subpopulations to Favor Post-AMI Cardiac Repair” in Advanced Science. The results of their study provide evidence for the role of M2EVin polarizing cardiac-resident CCR2+macrophages to an M2- like phenotype, resulting in reduced recruitment of circulating CCR2+monocytes, and an improved myocardial tissue microenvironment for cardiac tissue ......2023-06-01

Endometriosis, characterized by the growth of endometrium-like tissue outside the uterus, is a common gynecological disorder in women of childbearing age and can cause pain and infertility. Its pathophysiology remains largely unknown, limiting diagnosis and treatment. Current treatment options are limited to pain-relieving hormonal drugs or surgical treatments such as hysterectomy or removal of lesions. However, the treatment has limited effectiveness and side effects. Recently, several studies have reported on endometriosis, which may provide help for the early diagnosis and treatment of endometriosis.1. A long-acting anti–IL-8 antibody improves inflammation and fibrosis in endometr......2023-05-26

Background:RNA 5-methylcytosine (m5C) modification plays critical roles in the pathogenesis of various tumors. However, the function and molecular mechanism of RNA m5C modification in tumor drug resistance remain unclear.Methods:The correlation between RNA m5C methylation, m5C writer NOP2/Sun RNA methyltransferase family member 2 (NSUN2) and EGFR-TKIs resistance was determined in non-small-cell lungCancer(NSCLC) cell lines and patient samples. The effects of NSUN2 on EGFR-TKIs resistance were investigated by gain- and loss-of-function assays in vitro and in vivo. RNA-sequencing (RNA-seq), RNA bisulfite sequencing (RNA-BisSeq) and m5C methylated RNA immunoprecipitation-qPCR (MeRIP-qPCR)......2023-05-26

Myasthenia gravis(MG)is an autoimmune disease causing neuromuscular junction (NMJ) impairment, characterized by weakness and easy fatigability on exertion involving different skeletal muscle districts. The autoimmune attack is mediated by autoantibodies targeting key functional and structural NMJ proteins: the acetylcholine receptor (AChR), the muscle-specific kinase receptor (MuSK) or the lowdensity lipoprotein receptor-related protein 4 (LRP4).Recommendations for MG treatment have been published. However, treatment improvement of myasthenic patients is still a medical need as a substantial proportion of them are refractory or intolerant. Recently, several papers have reported studies......2023-05-23

On March 27, 2023,Lian-Wen Qi and Lei Zhang, State Key Laboratory of Natural Medicines, China Pharmaceutical University, China, and their team published a paper titled “Neuraminidase 1 promotes renal fibrosis development in male mice” in Nature Communications. This study characterizes a promotor role for NEU1 in renal fibrosis and suggests a potential avenue of targeting NEU1 to treat kidney diseases.The antibody[FITC-Linked Polyclonal Antibody to Kidney Injury Molecule 1 (Kim1),LAA785Mu81] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.The functions of the influenza virus neuraminidase has been well documented but those of the mamma......2023-05-22