Insulin is the key hormone for regulation of blood glucose and, generally, normoglycaemia is maintained by the balanced interplay between insulin action and insulin secretion. Importantly, the normal pancreatic β-cell can adapt to changes in insulin action—ie, a decrease in insulin action is accompanied by upregulation of insulin secretion (and vice versa). However, there is a limit to this regulation, and when β-cell dysfunction or insulin resistance occurs, glucose tolerance is impaired leading to type 2 diabetes. Recently, a number of papers have reported the related studies of blood glucose metabolism, providing help for the prevention and treatment of such metabolic diseases.1......2023-04-10

On March 2, 2023,Jin-Peng Sun, Key Laboratory Experimental Teratology of the Ministry of Education and Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, China, and his team published a paper titled “Unsaturated bond recognition leads to biased signal in a fatty acid receptor” in Science. They revealed how GPR120 differentiates rigid double bonds and flexible single bonds and may facilitate rational drug design targeting to GPR120.The kits [ELISA Kit for Inositol Triphosphate (IP3), CEC037Ge] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Individual fr......2023-04-10

Myocardial infarction(MI) is a term for anevent of heart attack. MI occurs when blood stops flowingproperly to a part of the heart, and the heart muscle isinjured because of lack of oxygen supply. And one of thecoronary arteries which supplies blood to the heart develops a blockage due to an unstable buildup of plaques, whiteblood cells, cholesterol and fat. If the event becomes serious then it is called as acute myocardialinfarction(AMI). Because adult cardiomyocyteshave little regenerative capacity, myocardial tissue lost in MIis replaced with fibrotic tissue, leading to cardiac dysfunction and Heart failure (HF).Recently, a number of papers have reported the research on cardiomyocyt......2023-03-31

On January 31, 2023, Yaoxing Chen, Neurobiology Laboratory, College of Veterinary Medicine, China Agricultural University, China, and his team published a paper titled “Gut microbiota-derived metabolites mediate theneuroprotective effect ofmelatonin incognitive impairment induced bysleep deprivation” in Microbiome. Their research showed that gut microbes and their metabolites mediate the ameliorative effects of melatonin on sleep deprivation-induced cognitive impairment.The kits [ELISA Kit for Tumor Necrosis Factor Alpha (TNFa), SEA133Mu; ELISA Kit for Interleukin 6 (IL6), SEA079Mu; ELISA Kit for Interleukin 4 (IL4), SEA077Mu; ELISA Kit for Interleukin 10 (IL10), SEA056Mu] of Cloud......2023-03-23

Lung cancer is the leading cause of cancer-related death worldwide, with non-small cell lung cancer (NSCLC) being the most common type (~85%). NSCLCs are subdivided into lung adenocarcinomas (LUADs;~50%), lung squamous cell carcinomas (LUSCs;~30%), and others (~20%). Although disease understanding, treatment options, and outcomes for lung cancer are improving, survival continues to be low.5-year survival in populations with lung cancer varies from 4-17% depending on stage and regional differences. Therefore, it is necessary to explore the underlying mechanisms of lung cancer development to support the design of new targeted therapeutic agents.1. KMT2D deficiency drives lung squamous ce......2023-03-22

On February 6, 2023, L. Tanner, Respiratory Medicine, Allergology, & Palliative Medicine, Department of Clinical Sciences Lund, Lund University and Skåne University Hospital, Sweden, and his team published a paper titled “Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis in a murine lung fibrosis model” in Nature Communications. Their data suggest that the small molecule OGG1 inhibitor, TH5487, is a potentially clinically relevant treatment for idiopathic pulmonary fibrosis (IPF).The kits [ELISA Kit for Lactate Dehydrogenase (LDH), SEB864Mu] of Cloud-Clone brand was chosed in this article, we are so proud for supporting the reaserchers.Int......2023-03-15