Skeletal type I collagen is the most abundant form of collagen in the human body, accounting for about 90% ofbone mass. Type I collagen is mainly synthesized in bone tissue. The first synthesis is procollagen. There is anextended peptide at the N-terminal and C-terminal of the type I procollagen, which is called type I procollagenN-terminal propeptide (PINP). And type I procollagen C-terminal propeptide (PICP); when type I procollagen issecreted outside the cell by osteoblasts, the N-terminal and C-terminal prolonged peptides are cleaved byproteases, except for a small amount deposited in the bone matrix, a large number will enter the blood circulationand eventually be cleared by the l......2019-08-05

Brain Natriuretic Peptide (BNP), also known as B-type Natriuretic Peptide, which is mainly synthesized and secreted by ventricularmyocytes. The main factors to stimulate BNP secretion are the changes in ventricular load and wall tension. It plays a significant rolein regulating the homeostasis of blood pressure and blood volume, diuresis and so on. BNP is species-specific. Rat BNP iscomposed of 45 amino acids, while pig, dog, and human BNP are composed of 32 amino acids. The gene fragment of human BNP islocated at the distal end of the short arm of chromosome 1 and is linked to the upstream ANP fragment. its reverse transcriptionaldeoxyribonucleic acid (cDNA) consists of 1900 nucleotid......2019-08-02

In July 2019, Literature of Cloud Clone products has exceeded 240. Cloud-Clone could provide multipleproteins, antibodies and ELISA kit, which has been praised by customers. （For more information, please visit: www.cloud-clone.com/www.uscnk.cn）2019-08-01

Insulin is a protein hormone secreted by islet beta cells in the pancreas. Insulin is involved in regulating glucosemetabolism and controlling blood sugar balance. It can be used to treat diabetes mellitus. The main physiologicalfunction of insulin is to regulate the metabolic process. Glucose metabolism: promoting the uptake and utilizationof glucose by tissue cells, promoting glycogen synthesis, inhibiting gluconeogenesis and lowering blood sugar;Fat metabolism: promoting fatty acid synthesis and fat storage, reducing fat decomposition; Protein: acceleratingthe entry of amino acids into cells, promoting all links of protein synthesis to increase protein Quality synthesis.Insulin is t......2019-07-24

Testosterone is a steroid hormone secreted by male testes or female ovaries. The adrenal gland also secretes asmall amount of testosterone, which has two effects on humans and other vertebrates: directly or in the form ofserum DHT to activate androgen receptors; and converted to estradiol to activate some estrogen receptors. Freetestosterone is transported to the cytoplasm of target tissue cells, binds to androgen receptors, or is converted toserum DHT by 5a-reductase. DHT also binds to androgen receptors (which are more stable, and the malehormone intensity of DHT is about 2.5 times that of testosterone). Testosterone receptors or serum DHTreceptors undergo structural changes that all......2019-07-19

Type II cardiorenal syndrome (CRSII) is one ofthemost severe cardiorenal syndrome.The renal impairmentorrenal insufficiencyiscaused by chronic cardiac insufficiency. And renal insufficiency also determines the prognosis of patients with Chronic heart failure (CHF) to a certain extent. At present, the acquaintanceof CRSII is very limited. Due to its high incidence, poor prognosis, littleknowledgeabout its pathogenesisandlack of effective measures, it is still a difficult problem for clinicians. Academician Hou FanFan and his team have made a breakthrough in the pathogenesis research of CRSII. And theirresearch results "the Wnt/beta - catenin signaling mediates both heart and kidney......2019-07-19