Heat shock proteins (heat shock protein, HSP) are a group of proteins rapidly induced by heat shock. An important feature in the biological world is that they are highly conserved in evolution. In recent years, HSP90a is the first one to be discovered and defined as the tumor marker by Chinese among more than 30 tumor biomarkers for tumor diagnosis worldwide. The others were defined by scientists in other countries. Cloud-Clone Corp. has concerned about this biological hotspot. It is well known that the HSPs are highly conserved. By aligning the sequences of the full length HSP90a from different species, such as human, rat, mouse, Guinea pig, pig, sheep, house, etc, the R&D Center ......2015-01-13

Anterior gradient protein 2 homolog (AGR2), a secretory protein localized in the endoplasmic reticulum, which was primary expressed in the trachea, lung, stomach, small intestine, colon and prostate. As it closely interacted with Mucin 2, ARG2 has been frequent mentioned in tumor related researches. Cloud-Clone Corp. has developed ARF2 protein, antibodies and series ELISA kits for researchers. AGR2 protein is encoded by 175 amino acids. After epitope analysis of functional domains, full length protein (Arg21~Leu175) excluding signal peptide sequences were chosen as the immunogen. This sequence retained whle antigenic epitopes, which would also be more convenient for researchers to con......2015-01-13

gABA（Gamma-Aminobutyric Acid）is the main inhibitory neurotransmitter of central nervous system in mammal, which mainly reduces the excitability of neurons. Besides the ability of directly adjusting the muscle tensity, gABA also has other functions, for instance, people will feel anxious and tired when he/she lacks gABA in the body. Consequently, gABA has great influences on normal physiological function of human being. gABA is a natural non-protein amino acid, which shares same molecular weight in different species. Aiming at this, Cloud-Clone Corp. developed a series of detection tools on gABA which includes coupling molecules, antibodies and Elisa kits. The development and mar......2014-12-11

In recent years, obesity has increased dramatically. The metabolic diseases caused by obesity, including hypertension, coronary heart disease, high cholesterol, diabetes, fatty liver and gallbladder disease, cholelithiasis, etc. show a significant increase, obesity has gradually become one of the major health problems world widely. It is reported that the adipose tissue, as a secretary organ, can secrete proinflammatory and anti-inflammatory adipocytokines. These factors are beneficial to health. And the disorder of adipocytokine secretion may be the main reason for human obesity. Secreted frizzled-related protein 5 (SFRP5), belonging to secreted frizzled related protein (SFRP) famil......2014-12-11

Recently, the global incidence of nephropathy showed an increasing trend. Besides cancer and heart disease, as the third largest "killer", it is very difficult for clinical physicians to make the diagnosis of early renal disease. This is mainly due to patients with early renal disease have no obvious symptoms, which is easy to delay treatment. So far, the indicators to determine kidney damage includes urine osmolality, osmotic pressure, serum creatinine, urea nitrogen, creatinine clearance rate and so on, but when these indicators increased, in most cases, serious kidney damage or irreversible damage has already appeared. Therefore, looking for new indicators for early detect......2014-12-11

Western Blot is a kind of experiment which is usually used for primarily verifying gene encoded products and discriminating the difference of protein quantity among different samples. As Western Blot includes lots of steps and reagents, when the result is not consistent to the predicted one, especially, all negative result or all positive results were shown, it is a very tough task to analyze what is wrong in the experiment. Based on this, it is recommended that a suitable reference system should be set up in a strict Western Blot experiment, and the reference system will be helpful for result analysis. A common used reference system includes several references, for instance, molecular......2014-12-11