My name is B-type natriuretic peptide, also called Brain Natriuretic Peptide (abbreviated BNP). Everyone calls me that since I was found in pig brain. I am mainly derived from the ventricle. In order to make everyone to know more about me, first of all, let me talk about my experience. Human cardiac cells secrete B-type natriuretic peptide (His27-His134), when ventricular volume overloads or pressure load increases, some endonucleases cleave B-type natriuretic peptide to form N-terminal B-type natriuretic peptide (NT-proBNP, His27-Arg102) and me (BNP, Ser103-His134). I have biological activities and play multiple roles in natriuretic, diuretic, antihypertensive and smooth muscle relaxa......2014-10-23

Cell cycle is a series of ordered events that take place in a cell from the first division to the next one. Cell cycle can be divided in two phases: interphase and mitotic (M) phase. During mitotic phase (M phase) , a series of changes take place in cellular modality and structure, including division of nucleus, condensation of chromosomes, appearance of spindle and equal distribution of chromosomes to two daughter cells, genetically identical to each other. It is well known that there is a common mechanism to regulate the mitotic phase of the cell cycle in all the eukaryote cells from yeast to human. MPF, a protein kinase, can phosphorylate multiple proteins to change their structure ......2014-10-23

1. Introduction Thyroid hormones are tyrosine monoiodide produced by thyroid follicular epithelial cells, this kind of hormone includes tetraiodothyronine( Thyroxine, T4), Triiodothyronine (T3), and reverse T3（rT3）. Both T3 and T4 have physiological activity, but with different action time and intensity. T4 has low physiological activity, slow reaction, and long functioning time, while T3 is totally on the contrary. The in vivo study shows, it’s T3 that works in physiological action and most of T4 functions when they turn to T3. That is to say, T4 is more likely a Prehormone, and rT3 does not have obvious physiological activity. T4 get deiodination by deiodinase, which is......2014-10-23

N-Terminal Pro-Brain Natriuretic Peptide (NT-proBNP) is synthesized by heart muscle cells, after secreted into the blood, it will be decomposed into BNP (the concrete introduction of the BNP, please pay attention to BNP - important markers of heart failure) and NT-BNP by endoproteinases (figure 1). As NT-BNP is characterized by non-biological activity, long half-life in the body, and easy to track for a long time, so it can be used as a clinical marker for cardiovascular disease surveillance, and cardiovascular researchers at home and abroad show great interest in it. In 2004 and 2008, the international experts systematically elaborated characteristics and clinical applications of BNP ......2014-10-23

Alzheimer's disease (AD), the most common cause of dementia, was named after its founder, German psychiatrist and neuropathologist Alois Alzheimer. The main symptom of AD is continuously nerve dysfunction, and its main pathogenic symptom is atrophy of cerebral cortex and certain subcortical region. With the progress of the disease, the patients will loss their long-term memory and physical function gradually, and ultimately lead to death. Because AD is becoming a great public health crisis, research programs about the disease are increasing recently. While exploring the mechanism of the disease, three hypotheses had been established. For each of the hypothesis, Cloud-Clone Corp......2014-10-23

CUZD1 is strictly regulated by estrogen in two key reproductive tissues, the uterus and oviduct. Spatio-temporal analyses reveal that CUZD1 mRNA is expressed in a highly stage-specific manner in the uterus and oviduct, and its expression is restricted to the surface epithelium of both of these tissues. Nucleotide sequence analysis of the full-length CUZD1 cDNA indicates that it has an open reading frame of 1821 nucleotides encoding a putative protein of 607 amino acids with a single transmembrane domain and a short cytoplasmic tail. Although the precise function of CUZD1 is not clear, presently, its unique pattern of expression in the uterus and oviduct, and its regulation by estrogen,......2014-04-11